You are going to need conversion motor mounts, a E body hemi K frame or have your K frame converted (assuming you are using a 426 that uses the original mounting configuration, there are some like the Mopar Performance blocks that had the same mounting ears as a 440). There is a guy floating around FBBO that converts your K frame and once converted its like stock.
You will need to change your torsion bars if you want any kind of decent ride and the car to handle at all. You should add at least torque boxes on all 4 corners but I would also add sub frame connectors. You might want to upgrade the leaf springs and perhaps the rearend as well (many people have used an 8 3/4 behind a 426 so don't let the hype scare you unless you are making big power). You should upgrade the fuel lines to at least 3/8", and you will probably want a new driveshaft with larger U joints.
Obviously the hemi will require unique exhaust which can be a challenge to some but other than that it isn't that big of a deal. Despite the 426 being "unique" its just an engine at the end of the day (albeit a very large one).
Look it isn't rocket science and many people have done it, some better than others. Think it through, make a good plan and execute it.